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Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
Published on: June 20, 2014
Gated magnetic resonance imaging of the normal and diseased heart
Insights
Cardiac magnetic resonance (MR) imaging with gating improves visualization of cardiovascular structures. Combined cardiac and respiratory gating offers superior image quality but increases scan time for cardiac imaging.
Area of Science:
- Cardiovascular Imaging
- Medical Diagnostics
- Radiology
Background:
- Cardiac magnetic resonance (MR) imaging is a key tool for cardiovascular assessment.
- Optimizing image acquisition techniques is crucial for accurate diagnosis.
Purpose of the Study:
- To evaluate the diagnostic utility of gated cardiac MR imaging.
- To compare image quality between gated and nongated techniques, and between cardiac-gated and combined cardiac-respiratory-gated imaging.
Main Methods:
- Gated cardiac MR imaging was performed on 23 subjects (2 volunteers, 21 with cardiovascular abnormalities).
- Images were correlated with clinical data, ECGs, and cardiac catheterization.
- Acquisition techniques included cardiac gating and combined cardiac-respiratory gating.
Main Results:
- Gated cardiac MR images were superior to nongated images.
- Combined cardiac and respiratory gating yielded better results than cardiac gating alone, albeit with longer acquisition times.
- Coronary arteries were visualized in 30% of cases; myocardial infarcts were detected in 55% of relevant patients.
- Normal cardiac anatomy was well visualized; coronary atherosclerosis and signal changes in subacute infarcts/myocarditis were not observed.
Conclusions:
- Gated cardiac MR imaging enhances visualization of cardiac anatomy and pathology.
- Combined gating improves image quality but necessitates longer scan durations.
- The technique shows potential for diagnosing myocardial infarcts and assessing cardiac structures, though coronary artery visualization remains limited.
Abstract:
Gated cardiac magnetic resonance (MR) images were obtained in two normal volunteers and 21 adults with a variety of cardiovascular abnormalities. The images were correlated with data from clinical examinations, electrocardiograms, and cardiac catheterization. Gated cardiac images were superior to nongated images. Combined cardiac and respiratory gated images were superior to images obtained with cardiac gating only, but acquisition time was longer. Portions of the coronary arteries were visualized in seven of 23 examinations (30%), and subacute and old myocardial infarcts were seen in five of nine patients (55%) as areas of thinned myocardium. No signal changes were observed in the patients with subacute infarctions or the patient with myocarditis. Coronary atherosclerotic lesions were not visualized in any of the patients. Normal cardiac anatomy (chambers, valves, and papillary muscles) was well visualized. Examples of aortic stenosis and atherosclerosis of the abdominal aorta are shown.
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