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[Stress and urolithiasis].

O Schmucki, R Asper, C Zortea

    Urologia Internationalis
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Short electric impulses induced stress in rats, altering urine composition. This stress response increased uric acid and inorganic phosphorus while decreasing potassium and magnesium, potentially increasing urolithiasis risk.

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    Area of Science:

    • Physiology
    • Urology
    • Toxicology

    Context:

    • Stress impacts physiological functions.
    • Animal models are crucial for studying stress responses.
    • Urine analysis provides insights into metabolic changes.

    Purpose:

    • To investigate the effect of acute, repetitive stress on the 24-hour urine composition of young male Wistar rats.
    • To correlate observed changes in urine electrolytes and metabolites with stress indicators.
    • To assess the potential risk of urolithiasis development following stress exposure.

    Summary:

    • Exposure to short, repetitive, weak electric impulses served as a stressor in young male Wistar rats.
    • Stress induced significant changes in 24-hour urine composition, including reduced potassium and magnesium levels, and increased inorganic phosphorus and uric acid concentrations.

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  • Adrenal gland hypertrophy confirmed the stress procedure's efficacy.

    • Impact:

    • Findings suggest a potential predisposition to urolithiasis due to altered urinary stone promoters (uric acid, inorganic phosphorus) and inhibitors (potassium, magnesium).
    • This study highlights the intricate relationship between stress, mineral metabolism, and urinary stone formation.
    • Results provide a basis for further research into stress management and prevention of urolithiasis.