[Use of foaming and nonfoaming gentamycin tablets in treating cows with chronic endometritis]

Biopharmaceutic and therapeutic investigations were carried out with foaming and nonfoaming gentamycin sulfate tablets. The experiments were conducted with a total of 100 cows affected with chronic inflammation of the uterus. Both types of tablets, containing 30,000 IU of gentamycin sulfate each were introduced into the uterus via Andreev's catheter, bimanually or by means of a vaginal speculum and Albrechtzen's clamp, at the rate of 10. Followed up were the serum levels, the excretion with the milk, and the content in the uterine secretion of gentamycin after using the tablets. There was no statistically significant difference in the serum levels of gentamycin as initiated by the two types of tablets. In milk the peak values reached 0.02 micrograms/cm3, and in uterine washings (with 15 cm3 isotonic solution of sodium chloride) the proper levels were established up to 74nd hour. Demonstrated was the therapeutic effect in the treatment of cows with chronic endometritis - 77.4 per cent with the use of foaming and 71.4 per cent with the use of nonfoaming tablets. There was also a rising trend with the conception rate in the treatment of sterile cows (otherwise having no signs of uterine inflammation) with the use of nonfoaming tablets of gentamycin sulfate at the rate of 5, introduced 24 hours after insemination.