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Related Experiment Videos

Behavioral activation by enkephalins in mice.

R J Katz, B J Carroll, G Baldrighi

    Pharmacology, Biochemistry, and Behavior
    |April 1, 1978
    PubMed
    Summary
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    Long-lasting enkephalin analogues increased psychomotor activity in mice, an effect reversed by naloxone. Naloxone also reduced activation in novel environments, suggesting endogenous opiates facilitate behavioral excitation.

    Area of Science:

    • Neuroscience
    • Behavioral Pharmacology

    Background:

    • Enkephalins are endogenous opioid peptides involved in pain and reward pathways.
    • Opioid receptors play a role in modulating motor activity and behavioral responses.

    Purpose of the Study:

    • To investigate the effects of long-lasting enkephalin analogues on psychomotor activity in mice.
    • To determine the role of endogenous opiates in behavioral excitation.

    Main Methods:

    • Intraventricular administration of D--Ala2Leu and Met enkephalin-amides to mice.
    • Observation and characterization of motor syndromes.
    • Pretreatment with naloxone to assess its effects on enkephalin-induced activity and novel environment responses.

    Main Results:

    Related Experiment Videos

  • Sustained elevation of psychomotor activity, characterized by stereotyped behaviors, following enkephalin analogue injection.
  • Reversal of enkephalin-induced motor syndromes by naloxone.
  • Naloxone reduced initial activation in a novel environment.

    • Conclusions:

    • Long-lasting enkephalin analogues induce sustained psychomotor excitation in mice.
    • Endogenous opiates likely facilitate behavioral excitation in mice.
    • Naloxone, an opioid antagonist, modulates both enkephalin-induced and environmentally-induced behavioral activation.