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Midazolam for upper gastrointestinal endoscopy.

P Kawar, K G Porter, E K Hunter

Annals of the Royal College of Surgeons of England

|July 1, 1984

Summary

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Midazolam, a water-soluble benzodiazepine, offers an acceptable alternative to diazepam for upper gastrointestinal endoscopy. It provides notable absence of injection pain and improved operating conditions when combined with pentazocine.

Area of Science:

Pharmacology
Gastroenterology
Anesthesiology

Background:

Midazolam is a water-soluble benzodiazepine used for sedation.
Upper gastrointestinal endoscopy requires effective sedation for patient comfort and procedural success.

Purpose of the Study:

To evaluate midazolam as a sedative agent for upper gastrointestinal endoscopy.
To compare midazolam with diazepam and assess its efficacy alone and in combination with pentazocine.

Main Methods:

A comparative study involving 400 patients receiving midazolam (alone or with pentazocine) and 68 patients receiving diazepam.
Assessment of injection pain, patient cooperation, operating conditions, and recovery time (pegboard test).

Main Results:

Related Experiment Videos

Midazolam demonstrated a notable absence of injection pain.
Operating conditions were significantly improved when midazolam was combined with pentazocine.
No significant differences in patient cooperation or recovery times were observed between groups.

Conclusions:

Midazolam is a suitable alternative to diazepam for sedation during upper gastrointestinal endoscopy.
The combination of midazolam and pentazocine enhances procedural operating conditions.