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[Infectious endocarditis in children].

A Zghaib, R Karam, F Attie

    Archivos Del Instituto De Cardiologia De Mexico
    |March 1, 1984
    PubMed
    Summary
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    Pediatric infective endocarditis is a growing concern, often linked to rheumatic or congenital heart disease. Delays in diagnosis and complications like embolism contribute to a high mortality rate, emphasizing the need for timely intervention.

    Area of Science:

    • Pediatric Cardiology
    • Infectious Diseases
    • Cardiovascular Surgery

    Context:

    • Advances in congenital heart disease surgery increase adult survival.
    • Infective endocarditis in childhood is a rising clinical challenge.
    • Study conducted at INC pediatric cardiology ward (1977-1981).

    Purpose:

    • To analyze the clinical characteristics, complications, and outcomes of infective endocarditis in pediatric patients.
    • To identify common underlying conditions and etiological agents.
    • To evaluate treatment efficacy in cases with negative blood cultures.

    Summary:

    • 32 pediatric cases of infective endocarditis studied, with a male predominance (62.5%).
    • Common underlying conditions included rheumatic heart disease (40.7%), congenital heart disease (15.6%), and postoperative states (43.7%).

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  • Average diagnostic delay was 43 days; Staphylococcus and Streptococcus were most frequent isolates. Peripheral and pulmonary embolism occurred in 34.4% of cases. Antibiotic combinations (ampicillin/oxacillin + aminoglycosides) showed success in negative blood culture cases. Mortality rate was 53%.

    • Impact:

    • Highlights the significant morbidity and mortality associated with pediatric infective endocarditis.
    • Underscores the importance of early diagnosis and management in high-risk pediatric populations.
    • Provides insights into effective antibiotic strategies for culture-negative endocarditis.