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Leucocyte depleted blood.

A S Hughes

    Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Non-haemolytic febrile transfusion reactions (NHFTR) can be prevented by transfusing leukocyte-depleted red cells. Various methods exist, with filtration and sedimentation offering effective leukocyte depletion and minimal red cell loss.

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    Area of Science:

    • Transfusion Medicine
    • Immunology

    Background:

    • Non-haemolytic febrile transfusion reactions (NHFTR) are frequently linked to leukocyte antibodies, particularly in patients receiving multiple transfusions.
    • These reactions pose a clinical challenge, necessitating strategies to mitigate their occurrence.

    Purpose of the Study:

    • To review and compare various methods for leukocyte depletion of red blood cells.
    • To evaluate the efficacy and limitations of different techniques in preventing NHFTR.

    Main Methods:

    • Comparison of manual centrifugation, saline washing, sedimentation with polymers (dextran), filtration, microaggregate filtration, and freezing/thawing.
    • Assessment of leukocyte depletion efficiency and red cell loss for each method.

    Main Results:

    Related Experiment Videos

    • Manual centrifugation is least effective; saline washing can be tedious or cause red cell loss.
    • Sedimentation and filtration offer excellent leukocyte depletion with minimal red cell loss.
    • Microaggregate filtration is a cost-effective bedside option; freezing/thawing is effective but costly.

    Conclusions:

    • Leukocyte depletion of at least 80% is recommended for preventing NHFTR.
    • The optimal method depends on available resources, cost, clinical requirements (e.g., platelet depletion), and institutional experience.