Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amiodarone-induced ultrastructural changes in human eyes.

M Ghosh, C McCulloch

    Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
    |June 1, 1984
    PubMed
    Summary

    Amiodarone treatment can cause ocular side effects, including the formation of unique cellular structures in various eye tissues. Regular eye monitoring is recommended for patients on long-term, high-dose amiodarone therapy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Physiologically based toxicokinetic models in aggregate exposure: A review.

    Toxicology letters·2025
    Same author

    The Rehabilitation of Cognitive Impairment Following Stroke: A Commentary on a Systematic Review.

    British journal of neuroscience nursing·2024
    Same author

    Laser-direct-drive fusion target design with a high-Z gradient-density pusher shell.

    Physical review. E·2023
    Same author

    Psychological Impacts of Retained Bullets From the Perspective of Survivors.

    The American surgeon·2023
    Same author

    'Wine Glass' sign following COVID-19 vaccination in a previously healthy adult.

    Neurologia·2022
    Same author

    Lung cancer: Premalignant biology and medical prevention.

    Seminars in oncology·2022

    Area of Science:

    • Ophthalmology
    • Pharmacology
    • Cell Biology

    Background:

    • Amiodarone is an antiarrhythmic drug frequently used for cardiac conditions.
    • Long-term amiodarone use is associated with various systemic side effects.
    • Ocular toxicity is a known, albeit less common, adverse effect of amiodarone.

    Observation:

    • This study details ocular observations in 100 patients treated with amiodarone.
    • Pathological examination of eye tissues from two patients revealed specific ultrastructural changes.
    • Electron microscopy identified intracytoplasmic, membrane-bound lamellar bodies resembling myelin.

    Findings:

    • These lamellar bodies were found in multiple ocular tissues, including the cornea, conjunctiva, lens, iris, ciliary body, choroid, and retina.
    • The presence of these structures suggests a potential mechanism for amiodarone-induced ocular toxicity.
    • The distribution across various retinal layers indicates widespread cellular impact.

    Implications:

    • Patients undergoing long-term, high-dose amiodarone therapy require vigilant ocular monitoring.
    • Regular ophthalmological examinations are crucial for early detection of potential visual impairment.
    • Further research is needed to fully elucidate the clinical significance and progression of these ocular findings.

    Related Experiment Videos