Related Experiment Video

Updated: Jul 30, 2026

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
08:01

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

Farmer's lung serologies. An early manifestation of acute histoplasmosis

J C Starr, H H Hahn, L J Wheat

    Chest
    |August 1, 1984
    PubMed

    Insights

    Acute histoplasmosis cases showed positive precipitins against farmer's lung antigens. Further study revealed 40% of patients with acute histoplasmosis had positive precipitins against organic dust antigens.

    Area of Science:

    • Medical Mycology
    • Immunology
    • Infectious Diseases

    Background:

    • Histoplasmosis is a fungal infection often diagnosed through serologic tests.
    • Farmer's lung is a hypersensitivity pneumonitis caused by organic dust exposure.

    Observation:

    • Three acute histoplasmosis cases presented with positive precipitins against farmer's lung antigens.
    • An additional twelve patients with acute histoplasmosis were analyzed.

    Findings:

    • The initial three cases showed strong positive precipitins against farmer's lung antigens.
    • Forty percent of the additional patients with acute histoplasmosis also had positive precipitins against organic dust antigens.

    Implications:

    • This suggests a potential cross-reactivity or shared antigenic determinants between Histoplasma and organic dusts.
    • Further research is needed to clarify the immunologic relationship and diagnostic significance.
    • Consideration of organic dust exposure may be relevant in diagnosing histoplasmosis.

    More Related Videos

    Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis09:52

    Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

    Published on: March 9, 2018

    Microbiological Rapid On-Site Evaluation for Pulmonary Infectious Diseases03:22

    Microbiological Rapid On-Site Evaluation for Pulmonary Infectious Diseases

    Published on: March 1, 2024

    Related Concept Videos

    Pneumonia II: Pathophysiology01:29

    Pneumonia II: Pathophysiology

    The pathophysiology of pneumonia involves the following steps:
    Pulmonary Tuberculosis II01:28

    Pulmonary Tuberculosis II

    Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
    Here is a detailed explanation of its pathophysiology:
    Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
    Pulmonary Tuberculosis IV01:26

    Pulmonary Tuberculosis IV

    Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
    Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
    Atypical Pneumonia01:14

    Atypical Pneumonia

    Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
    Respiratory Syncytial Virus Disease01:29

    Respiratory Syncytial Virus Disease

    Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
    Toxoplasmosis01:28

    Toxoplasmosis

    Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...