[Mechanisms of disordered cardiac energy supply in transient coronary insufficiency]

Experiments conducted on 240 albino non-inbred male rats, using models of transitory coronary insufficiency of various duration (the period of myocardial ischemia lasted 10, 40 and 120 min), showed impaired energy supply to the heart in both periods of its ischemia and reperfusion in relation to three principal stages; first the synthesis of ATP, then the transportation and utilization of its energy. The period of ischemia was associated with disorders of predominantly the ATP synthesis and to a lesser degree of the transport and utilization of its energy. In the period of the post-infarction resumption of the coronary blood flow mostly affected were the mechanisms of the transportation and absorption of ATP energy by the effector apparatus of cardiomyocytes. At the early stage of myocardial reperfusion after a prolonged (40 and 120 min) local ischemia, the heart was damaged to a greater degree than in continuing ischemia of the same duration. The development of transitory coronary insufficiency following the preliminary administration of the antihypoxant gutimin is characterized by less marked disorders in the process of cardiac energy supply both in the period of myocardial ischemia and at the early stage of the reperfusion.