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Lung metabolism and systemic organ function.

H B Hechtman, D Shepro

    Circulatory Shock
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    The lungs perform metabolic functions impacting organ systems. Therapeutic maneuvers like positive end-expiratory pressure (PEEP) can alter lung metabolism, affecting hemodynamics and potentially causing respiratory failure.

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    Area of Science:

    • Pulmonary Medicine
    • Cardiovascular Physiology
    • Metabolic Research

    Background:

    • The lungs are increasingly recognized for their metabolic roles, influencing systemic organ function.
    • Pulmonary metabolic processes include neurotransmitter clearance, hormone activation/inactivation, and prostaglandin synthesis.
    • Lung-derived prostaglandins can cause hemodynamic instability.

    Purpose of the Study:

    • To explore the metabolic functions of the lungs.
    • To investigate the impact of pressure breathing and positive end-expiratory pressure (PEEP) on lung metabolism and systemic effects.
    • To reframe respiratory failure as a metabolic derangement.

    Main Methods:

    • Review of established pulmonary metabolic pathways.
    • Analysis of the effects of pressure breathing with hyperinflation on lung metabolism.

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  • Examination of the impact of positive end-expiratory pressure (PEEP) on fibrinolytic activity, cardiac output, and circulating factors.

    • Main Results:

    • Pressure breathing with hyperinflation stimulates pulmonary metabolism and increases fibrinolytic activity.
    • Positive end-expiratory pressure (PEEP) enhances fibrinolysis via plasminogen activator secretion.
    • PEEP reduces cardiac output and releases circulating factors with negative inotropic effects.

    Conclusions:

    • Lung metabolic processes significantly influence systemic organ function.
    • Therapeutic interventions like PEEP have profound metabolic consequences.
    • Respiratory failure should be considered a complex condition involving both gas exchange and metabolic derangements.