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[Insulin resistance with acanthosis nigricans: a case report]
Nihon Naibunpi Gakkai Zasshi
|June 20, 1982
Summary
This study details a boy with Type A syndrome, characterized by insulin resistance and acanthosis nigricans. The findings reveal a reduced number of insulin receptors as a key cause of his condition.
Area of Science:
- Endocrinology
- Metabolic Disorders
Background:
- Type A syndrome is a rare condition characterized by severe insulin resistance and acanthosis nigricans.
- It is often associated with genetic mutations affecting the insulin receptor.
Observation:
- A 12-year-old boy presented with symptoms of Type A syndrome.
- He exhibited extreme insulin resistance with very high insulin levels and normal blood glucose.
- Insulin binding to mononuclear cells was significantly reduced, indicating a problem with insulin receptors.
Findings:
- Analysis showed a normal affinity but a decreased number of insulin receptors on cell membranes.
- Other insulin antagonists were within normal limits, and no antibodies were detected.
- Fasting reduced insulin levels but did not alter receptor binding, suggesting the receptor decrease was not secondary to hyperinsulinemia.
Implications:
- This case highlights a reduced number of insulin receptors as a primary cause of insulin resistance in Type A syndrome.
- Understanding receptor defects is crucial for diagnosing and managing this rare endocrine disorder.