Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[HLA and IgA deficiency].

J Seignalet, F B Michel, R Guendon

    Revue Francaise De Transfusion Et Immuno-Hematologie
    |June 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Application of the WHO chronic respiratory diseases programme in Sub-Saharian Africa: problems in Senegal].

    Revue des maladies respiratoires·2004
    Same author

    Specific immunotherapy in rhinitis and asthma.

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2001
    Same author

    [From allergic rhinitis to sinus diseases (sinusitis/nasal polyps): epidemiologic and experimental links].

    Revue des maladies respiratoires·2000
    Same author

    [Asthma and rhinitis medications: pregnancy precautions].

    Presse medicale (Paris, France : 1983)·2000
    Same author

    [Corticosteroid therapy of asthma].

    Presse medicale (Paris, France : 1983)·2000
    Same author

    [Drug allergies: a public health problem].

    Bulletin de l'Academie nationale de medecine·2000
    Same journal

    [Probability of paternity related to probable ancestry].

    Revue francaise de transfusion et immuno-hematologie·1988
    Same journal

    [Iron and ferritin in 102 east Parisian blood donors].

    Revue francaise de transfusion et immuno-hematologie·1988
    Same journal

    [Genetic variants of human albumin: structural characterization of allotypes used as references for electrophoretic classification].

    Revue francaise de transfusion et immuno-hematologie·1988
    Same journal

    [Quantitative evaluation of serum IgG subclass levels by an immunoenzyme method].

    Revue francaise de transfusion et immuno-hematologie·1988
    Same journal

    [Development of reagents used in blood transfusion: 1992 horizon].

    Revue francaise de transfusion et immuno-hematologie·1988
    Same journal

    [Functional study of 11 monoclonal anti-Rh D IgG antibodies. Attempt to define selection criteria with regard to their use in Rh immunoprophylaxis].

    Revue francaise de transfusion et immuno-hematologie·1988
    See all related articles

    This study found no significant association between HLA-A or B antigens and immunoglobulin A (IgA) deficit in Caucasian patients. Further research into HLA-D and Ia genes is warranted for IgA insufficiency.

    Area of Science:

    • Immunogenetics
    • Human Leukocyte Antigen (HLA) system
    • Immunodeficiency

    Context:

    • Immunoglobulin A (IgA) deficit is a common primary immunodeficiency.
    • The Human Leukocyte Antigen (HLA) system plays a crucial role in immune regulation.
    • Previous studies have explored associations between HLA antigens and various immune disorders.

    Purpose:

    • To investigate the distribution of HLA-A and HLA-B antigens in Caucasian individuals with IgA deficit.
    • To determine if specific HLA-A or B alleles are associated with different types of IgA deficiency.
    • To review existing literature on HLA and congenital immune insufficiencies.

    Summary:

    • A comparison of HLA-A and B antigen frequencies was conducted between 50 Caucasian patients with IgA deficit and 300 healthy controls.

    Related Experiment Videos

  • Patients were categorized into partial selective IgA deficit, total selective IgA deficit, and IgA deficit with hypogammaglobulinemia groups.
  • While a slight increase in HLA-Aw19, HLA-B5, and HLA-BW17 was observed in the overall IgA deficit group, these findings were not statistically significant after correction. No specific associations were found when analyzing subgroups separately.
  • The study did not confirm previously reported increased frequencies of HLA-A1 and HLA-B8 in IgA deficit.

    • Impact:

    • This research indicates no clear association between specific HLA-A or B genes and IgA deficit.
    • The findings suggest that IgA insufficiency may not be directly linked to the investigated HLA loci.
    • Further investigation into HLA-D and Ia gene associations with IgA insufficiency is recommended, considering potential links to autoimmunity and allergy.