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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Drug Toxicity: Overview01:00

Drug Toxicity: Overview

Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...

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[Management of immune-related toxicities associated with immune checkpoints inhibitors: Data from the multidisciplinary meeting « ToxImmun » in Eastern Occitania].

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Related Experiment Video

Updated: Jul 15, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

[Drug allergies: a public health problem].

J Bousquet1, P Demoly, D Hillaire-Buys

  • 1Clinique des Maladies Respiratoires, INSERM U454, IFR3, Hôpital Arnaud de Villeneuve, CHU de Montpellier.

Bulletin De L'Academie Nationale De Medecine
|September 16, 2000
PubMed
Summary

Adverse drug reactions, including allergic and pseudoallergic types, affect many hospitalized patients. Diagnosis is challenging due to a lack of specific tools, impacting patient care and healthcare costs.

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Last Updated: Jul 15, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
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Area of Science:

  • Pharmacovigilance
  • Immunology
  • Clinical Medicine

Context:

  • Adverse drug reactions (ADRs) are a significant concern in healthcare settings.
  • Allergic and pseudoallergic reactions constitute a substantial portion of ADRs.
  • Current diagnostic methods for these reactions are insufficient.

Purpose:

  • To review epidemiological data on allergic and pseudoallergic drug reactions.
  • To highlight the incidence, mortality, and economic impact of these reactions.
  • To underscore the need for improved diagnostic tools.

Summary:

  • Adverse drug reactions affect 10-20% of hospitalized individuals, with up to one-third being allergic or pseudoallergic.
  • Allergic reactions involve immunologic mechanisms, while pseudoallergic reactions mimic these without specific immune markers.
  • Accurate diagnosis of these reactions is often difficult due to limited tools.

Impact:

  • Understanding the epidemiology of these reactions is crucial for patient safety.
  • This review provides insights into the incidence, mortality, and cost associated with drug hypersensitivity.
  • Highlights the gap in diagnostic capabilities for allergic and pseudoallergic drug reactions.