Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sickle cell trait: an update.

L N Johnson

    Journal of the National Medical Association
    |August 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Sickle cell trait (SCT) is not linked to major health issues like mortality or hospitalization. However, SCT is associated with rare conditions such as splenic infarction at high altitudes and offers protection against malaria.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evaluation of owner experiences and adherence to home-cooked diet recipes for dogs.

    The Journal of small animal practice·2015
    Same author

    Cryopreservation of buffy-coat-derived platelet concentrates in dimethyl sulfoxide and platelet additive solution.

    Cryobiology·2011
    Same author

    Enzymatic catalysis in crystals of Escherichia coli maltodextrin phosphorylase.

    Journal of molecular biology·2002
    Same author

    Structural studies on phospho-CDK2/cyclin A bound to nitrate, a transition state analogue: implications for the protein kinase mechanism.

    Biochemistry·2002
    Same author

    Structural basis for control by phosphorylation.

    Chemical reviews·2001
    Same author

    Xenopus phospho-CDK7/cyclin H expressed in baculoviral-infected insect cells.

    Protein expression and purification·2001
    Same journal

    Perioperative outcomes: Transforming healthcare.

    Journal of the National Medical Association·2026
    Same journal

    The intersection of infectious diseases and cardiovascular disease in Africa: A narrative review.

    Journal of the National Medical Association·2026
    Same journal

    Atrial fibrillation in chronic heart failure: prevalence and one-year outcome in the Ibadan chronic heart failure project.

    Journal of the National Medical Association·2026
    Same journal

    Corrigendum to ``Medical student perspectives of leadership development in community engagement'' [In Press].

    Journal of the National Medical Association·2026
    Same journal

    Ethno-racial trauma and well-being in medical education: A scoping review of U.S. physician trainees and medical students.

    Journal of the National Medical Association·2026
    Same journal

    Cuts to medicaid and the affordable care act: Negative consequences for the black community.

    Journal of the National Medical Association·2026
    See all related articles

    Area of Science:

    • Hematology
    • Genetics
    • Public Health

    Background:

    • A 1978 literature review by Sears addressed sickle cell trait (SCT).
    • Subsequent research has explored potential health risks associated with SCT.

    Purpose of the Study:

    • To review and synthesize current literature on the health implications of sickle cell trait.
    • To identify conditions statistically associated with SCT and assess their clinical significance.

    Main Methods:

    • Comprehensive literature review of published studies on sickle cell trait.
    • Analysis of data regarding associations between SCT and various health outcomes.
    • Evaluation of the frequency and clinical relevance of identified associations.

    Main Results:

    Related Experiment Videos

    • No association found between SCT and overall survival, mortality, morbidity, or hospitalization rates.
    • SCT is statistically linked to splenic infarction at high altitudes, pregnancy-related bacteriuria/pyelonephritis, hyposthenuria, hematuria, and delayed hyphema resolution.
    • These associated conditions are infrequent, necessitating consideration of other causes.
    • SCT demonstrates a significant association with reduced mortality from Plasmodium falciparum infection.

    Conclusions:

    • Sickle cell trait is generally not associated with adverse health outcomes or reduced survival.
    • While statistically linked to rare conditions, these associations are infrequent and require careful clinical evaluation.
    • Sickle cell trait confers a protective effect against severe Plasmodium falciparum malaria.