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Furosemide chronopharmacology
South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|December 18, 1982
Summary
The timing of furosemide administration does not alter its effects on electrolyte excretion or diuresis in healthy males. Furosemide tends to increase aldosterone and renin activity irrespective of administration time.
Area of Science:
- Pharmacology
- Endocrinology
- Nephrology
Background:
- Diurnal variations can influence drug efficacy and physiological responses.
- Understanding the impact of administration timing is crucial for optimizing diuretic therapy.
Purpose of the Study:
- To investigate diurnal variations in the effects of furosemide on electrolyte excretion, aldosterone, and renin activity.
- To determine if the time of furosemide administration affects its physiological impact.
Main Methods:
- Twelve healthy males received placebo or furosemide (40 mg) at 07:00, 13:00, and 19:00 in a crossover design.
- Measurements included electrolyte excretion, diuresis, serum aldosterone concentrations, and plasma renin activity.
Main Results:
- Furosemide administration time did not significantly affect sodium and potassium excretion or diuresis.
- A trend for furosemide to elevate serum aldosterone and renin activity was observed, independent of administration timing.
Conclusions:
- The diurnal rhythm does not appear to influence the acute effects of furosemide on electrolyte excretion and diuresis.
- Furosemide consistently impacts aldosterone and renin activity, regardless of when it is administered.