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Plasmid-linked drug resistance in Salmonella typhimurium in Kuwait
Abstract:
A total of 143 strains of S. typhimurium isolated from clinical cases in Kuwait were investigated for drug resistance. Multidrug resistance (3 or more drugs) was seen in 76.9% of the strains. The common resistance patterns were ASuT (16), AKSuT (20), ASSuT (14), CKSSuT (14), ACKSSuT (10), ACGKSSuT (15) and ACKGSSuTTm (8). MIC of resistant strains was usually high. Sixteen isolates were examined for the transferability of the resistance. All had R-plasmids, both autotransferable and non-autotransferable which could be mobilised by factor X.
Insights
Most Salmonella typhimurium clinical isolates in Kuwait show multidrug resistance, with common patterns including ampicillin, sulfonamides, and tetracycline. Resistance genes are often transferable via R-plasmids.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Salmonella typhimurium is a significant cause of human infections.
- Antimicrobial resistance in bacterial pathogens is a growing global health concern.
- Understanding resistance patterns in clinical isolates is crucial for effective treatment.
Purpose of the Study:
- To investigate the prevalence and patterns of drug resistance in Salmonella typhimurium clinical isolates from Kuwait.
- To determine the transferability of antimicrobial resistance.
Main Methods:
- Phenotypic drug resistance testing was performed on 143 S. typhimurium strains.
- Common resistance patterns were identified.
- Transferability of resistance was assessed in 16 selected isolates, focusing on R-plasmids.
Main Results:
- A high prevalence of multidrug resistance (resistance to 3 or more drugs) was observed in 76.9% of the strains.
- Specific common resistance patterns included AKSuT, ACGKSSuT, and ASSuT.
- All 16 examined isolates harbored R-plasmids, indicating the potential for resistance gene transfer.
Conclusions:
- Salmonella typhimurium strains from clinical cases in Kuwait exhibit extensive multidrug resistance.
- The presence of transferable R-plasmids suggests a mechanism for the spread of resistance within bacterial populations.
- These findings highlight the need for surveillance and strategies to combat antimicrobial resistance in the region.