Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Insulin resistance developing in children with IDDM.

L Cuttler, R M Ehrlich

    Diabetes Care
    |May 1, 1982
    PubMed
    Summary

    Three children with insulin-dependent diabetes mellitus (IDDM) developed insulin resistance (IR). Two cases involved high insulin antibodies, while one had hyperthyroidism, highlighting diverse causes of IR in pediatric diabetes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Percent body fat prediction equations for 8- to 17-year-old American children.

    Pediatric obesity·2013
    Same author

    Is diabetes mellitus preventable?

    Canadian family physician Medecin de famille canadien·2011
    Same author

    Juvenile diabetes mellitus.

    Canadian family physician Medecin de famille canadien·2010
    Same author

    Non-ketotic hyperosmolar coma.

    Canadian Medical Association journal·2010
    Same author

    Regulation of GHRH receptor gene expression in the neonatal and adult rat pituitary.

    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society·2001
    Same author

    Response to Malone et al.

    Diabetes care·2001

    Area of Science:

    • Pediatric Endocrinology
    • Metabolic Disorders
    • Immunology

    Background:

    • Insulin resistance (IR) is a complex condition impacting glycemic control in children with insulin-dependent diabetes mellitus (IDDM).
    • Understanding the diverse etiologies and clinical presentations of IR is crucial for effective management in pediatric populations.

    Observation:

    • A review of 1000 children with IDDM identified three cases of new-onset insulin resistance.
    • One patient with IDDM and cystic fibrosis, and another typical IDDM patient, presented with high insulin antibody titers and responded to sulfated insulin.
    • A third patient with IDDM and hyperthyroidism showed IR controlled by propylthiouracil, despite high anti-insulin antibodies.

    Findings:

    • Among 29 reported children with IDDM and IR, 71% had elevated insulin antibodies.
    • Associated illnesses were present in 41% of these pediatric patients.
    • Outcomes varied, with 67% improving, 21% persisting with IR, and 12% mortality.

    Implications:

    • This study underscores the importance of investigating underlying causes for IR in children with IDDM, including autoimmune responses and comorbid conditions.
    • Early identification and tailored treatment strategies are essential for managing IR and improving outcomes in pediatric diabetes.
    • The findings contribute to the limited literature on insulin resistance in children, particularly highlighting rare associations like cystic fibrosis and hyperthyroidism.

    Related Experiment Videos