Comparative aspects of pigmented nevi in children, youths and adults

Clinicomorphological correlations in children of different ages, youths, and adults with various pigmented nevi are analyzed to determine the diagnostic significance of certain structures. The study included 129 pigmented nevi surgically removed from 122 children, 27 from youths, and 133 from adult subjects. A comparative analysis of the reasons that caused the removal of the pigmented nevi made it possible to clarify a number of peculiarities of pigmented nevi in children that play an important role in the clinical and diagnostic aspects, as well as the decision of management policy. For diagnostic purposes, in the evaluation of pigmented nevi in children, particular attention should not be paid to the marked cellular proliferation of junctional melanoblasts, invasion of the epidermis by nevus cells, and pigmentation of the epidermis by melanin.