[Bactericidal activity of antibiotics as a function of pharmacokinetic constants. I. Experimental dynamic model...

In order to study the bactericidal effect of antibiotics in a system approaching actual therapy, a dynamic model which simulates concentration variations was developed. This was done using a dialysis intermediary. Three aminoglycosides (amikacin, gentamicin, tobramycin) were taken in a system resembling the serum rates of the normal individual. The apparatus is fairly accurate, the variation coefficients being of the order of 10 to 14%. This model enables the simulation of numerous therapeutic situations. It is however limited to only dialysable antibiotics.