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Updated: Aug 8, 2026

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
Published on: September 25, 2017
An association of carcinogenesis and decrease of cellular NAD concentration
Abstract:
It is postulated that a decrease in nicotinamide adenine dinucleotide (NAD) concentration has a primary association with carcinogenesis. The following observations are presented as evidence: (1) NAD and adenosine triphosphate (ATP) concentrations are lower in cancer cells; (2) chemical carcinogens and radiation can cause a lowering of NAD concentration in precancerous cells: (3) biosynthesis of NAD in Ehrlich ascites tumor cells is altered; and (4) NAD is involved in regulating deoxyribonucleic acid (DNA) synthesis. The lowering of NAD concentration would lead to the expression of oncogene and/or virogene according to the protovirus hypothesis, and the cellular characteristics of cancer cells can also be explained through the lowering of cellular NAD concentration. Experimental approaches are also proposed.
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