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An association of carcinogenesis and decrease of cellular NAD concentration.

K T Chung

    Zhonghua Minguo Wei Sheng Wu Ji Mian Yi Xue Za Zhi = Chinese Journal of Microbiology and Immunology
    |November 1, 1982
    PubMed
    Summary
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    A decrease in nicotinamide adenine dinucleotide (NAD) concentration is linked to cancer development. Lower NAD levels in cells may trigger oncogene expression, potentially driving carcinogenesis.

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Oncology

    Background:

    • Nicotinamide adenine dinucleotide (NAD) is crucial for cellular energy metabolism and DNA repair.
    • Altered cellular metabolism is a hallmark of cancer.
    • The precise role of NAD depletion in cancer initiation and progression requires further elucidation.

    Purpose of the Study:

    • To investigate the association between decreased nicotinamide adenine dinucleotide (NAD) concentration and carcinogenesis.
    • To explore the potential mechanisms by which NAD depletion may contribute to cancer development.

    Main Methods:

    • Comparative analysis of NAD and adenosine triphosphate (ATP) concentrations in cancer cells versus normal cells.
    • Assessment of the impact of chemical carcinogens and radiation on NAD levels in precancerous cells.

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  • Investigation of NAD biosynthesis pathways in tumor cells.
  • Examination of NAD's role in regulating deoxyribonucleic acid (DNA) synthesis.

    • Main Results:

    • Cancer cells exhibit lower concentrations of NAD and ATP compared to normal cells.
    • Exposure to carcinogens and radiation reduces NAD levels in precancerous cells.
    • Altered NAD biosynthesis is observed in Ehrlich ascites tumor cells.
    • NAD plays a role in regulating DNA synthesis.

    Conclusions:

    • A decrease in NAD concentration is postulated to be a primary factor in carcinogenesis.
    • Lowered NAD levels may lead to the expression of oncogenes or virogenes, consistent with the protovirus hypothesis.
    • The observed changes in cellular NAD concentration can explain the characteristics of cancer cells.