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Related Experiment Videos

Evaluation of amoxapine.

J L Kinney, R L Evans

    Clinical Pharmacy
    |September 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Amoxapine is a tricyclic antidepressant that blocks norepinephrine reuptake. It shows early therapeutic effects in some depression types but has no significant advantages over other antidepressants.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Psychiatry

    Background:

    • Amoxapine is a tricyclic dibenzoxazepine antidepressant.
    • It is chemically similar to the antipsychotic loxapine.
    • Amoxapine primarily blocks norepinephrine reuptuptake with minimal effect on serotonin.

    Purpose of the Study:

    • Review pharmacology, pharmacokinetics, clinical trials, side effects, and dosage of amoxapine.
    • Evaluate amoxapine's efficacy and safety in treating various depressive disorders.
    • Compare amoxapine's therapeutic onset and effects with other antidepressants like amitriptyline and imipramine.

    Main Methods:

    • Review of existing literature on amoxapine.
    • Analysis of animal studies on neurotransmitter reuptake inhibition.

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  • Examination of clinical trial data comparing amoxapine with amitriptyline and imipramine.
  • Compilation of reported side effects and pharmacokinetic data.

    • Main Results:

    • Amoxapine is rapidly absorbed orally, with peak serum concentrations in 1-2 hours.
    • It is widely distributed and highly protein-bound, with hepatic metabolism and urinary/fecal excretion.
    • Clinical trials suggest potentially earlier therapeutic effects in some patients compared to amitriptyline/imipramine, though differences were not always statistically significant.
    • Common side effects include hypotension, drowsiness, xerostomia, and constipation.

    Conclusions:

    • Amoxapine is an effective antidepressant for various depression types, including those with anxiety or agitation.
    • It demonstrates a favorable pharmacokinetic profile and a generally manageable side effect profile.
    • While effective, amoxapine does not present striking advantages over currently available antidepressant agents.