Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aspirin and dipyridamole decrease intimal hyperplasia in experimental vein grafts.

R L McCann, P O Hagen, J C Fuchs

    Annals of Surgery
    |February 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Note: Internal diamagnetic flux measurements on ASDEX Upgrade.

    The Review of scientific instruments·2018
    Same author

    Real-time diamagnetic flux measurements on ASDEX Upgrade.

    The Review of scientific instruments·2016
    Same author

    Application of AXUV diode detectors at ASDEX Upgrade.

    The Review of scientific instruments·2014
    Same author

    First observation of edge localized modes mitigation with resonant and nonresonant magnetic perturbations in ASDEX Upgrade.

    Physical review letters·2011
    Same author

    Comparison of transposed brachiobasilic fistulas to upper arm grafts and brachiocephalic fistulas.

    Kidney international·2001
    Same author

    Intracavernosal injections of vascular endothelial growth factor protects endothelial dependent corpora cavernosal smooth muscle relaxation in the hypercholesterolemic rabbit: a preliminary study.

    International journal of impotence research·2001
    Same journal

    Real-world Safety and Performance of the Symani Surgical System® in Microsurgical Reconstructive Procedures: Primary Results from the PRIMO Study.

    Annals of surgery·2026
    Same journal

    Revisiting Simultaneous Liver and Kidney Transplantation from Donors After Circulatory Death in the Era of Machine Perfusion Technologies: A US Nationwide Analysis of 10,687 Cases.

    Annals of surgery·2026
    Same journal

    The International Medical Graduate Paradox.

    Annals of surgery·2026
    Same journal

    Defining the Incremental Value of Endoscopic Ultrasound in Assessing Pancreatic Cystic Neoplasms.

    Annals of surgery·2026
    Same journal

    Trends in Metabolic and Bariatric Surgery and GLP-1 Receptor Agonist Use Among Adolescents with Severe Obesity.

    Annals of surgery·2026
    Same journal

    The Ambulatory Surgery Center Paradox: Why 60% of Surgeries Occur Where 2% of AI Research Happens.

    Annals of surgery·2026
    See all related articles

    Antiplatelet therapy with aspirin and dipyridamole reduced vascular intimal hyperplasia in rhesus monkeys. This suggests that antiplatelet agents can be effective in preventing or treating this condition.

    Area of Science:

    • Vascular Biology
    • Platelet Function
    • Smooth Muscle Cell Biology

    Background:

    • Vascular intimal hyperplasia is a significant complication after vascular surgery.
    • Platelet-derived growth factors are implicated in the pathogenesis of intimal hyperplasia.

    Purpose of the Study:

    • To evaluate the efficacy of antiplatelet therapy in preventing vascular intimal hyperplasia.
    • To assess the role of intimal injury versus adventitial stripping in hyperplasia development.

    Main Methods:

    • Rhesus monkeys received aspirin and dipyridamole or placebo.
    • Vascular grafts were created, and intimal injury or adventitial stripping was induced.
    • Histological analysis and photographic gravimetric methods were used to assess hyperplasia and luminal area.

    Related Experiment Videos

    Main Results:

    • Intimal injury, not adventitial stripping, led to hyperplasia in placebo group.
    • Antiplatelet therapy significantly reduced intimal hyperplasia in injured vessels and grafts.
    • Drug-treated animals showed less relative intimal area and greater luminal area in grafts.

    Conclusions:

    • Antiplatelet therapy effectively reduces vascular intimal hyperplasia.
    • Intimal injury is a key factor in hyperplasia development.
    • Platelet-derived factors play a crucial role in the pathogenesis of intimal hyperplasia.