Resistance to gonorrhea possibly mediated by the genital microbial flora

The proximal male urethra is normally sterile, but microorganisms exist in the distal urethra. The members of the distal urethra flora change with sexual activity. Components of the urethral flora may include aerobic bacteria, anaerobic bacteria, fungi, and mycoplasmas. These microorganisms may function in the urethra's resistance to some pathogens. Certain patients with urethral meningococci and staphylococci resisted infection following exposure to women with gonococcal cervicitis. In vitro assays showed these bacteria capable of inhibiting Neisseria gonorrhoeae. The inhibition also occurred in vivo, using the animal subcutaneous chamber model of gonococcal infection.