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Related Experiment Videos

Drinking in the rhesus monkey: peripheral factors.

S Maddison, R J Wood, E T Rolls

    Journal of Comparative and Physiological Psychology
    |April 1, 1980
    PubMed
    Summary

    Drinking termination in rhesus monkeys is not solely due to mouth or stomach cues. Intestinal signals, specifically from the duodenum, are crucial for regulating water intake.

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    Area of Science:

    • Physiology
    • Neuroscience
    • Animal Behavior

    Background:

    • Understanding the physiological mechanisms that regulate thirst and drinking behavior is essential for comprehending homeostatic processes.
    • Previous research suggests that both sensory input from the oropharyngeal region and gastric distension play roles in satiety, but the precise contributions remain debated.

    Purpose of the Study:

    • To investigate the role of oropharyngeal, gastric, and intestinal factors in the termination of drinking behavior in rhesus monkeys.
    • To determine if signals originating beyond the stomach are necessary for inhibiting continued water intake.

    Main Methods:

    • Rhesus monkeys were surgically prepared with chronic cannulae in the stomach and duodenum.
    • Water intake was measured under conditions of free drinking, gastric drainage (sham drinking), and duodenal drainage (sham drinking).
    • Duodenal infusions of water and saline were administered to assess their effects on sham drinking.

    Main Results:

    • Free drinking resulted in a mean intake of 137 ml.
    • Gastric and duodenal sham drinking led to significantly increased water intake (878 ml and 634 ml, respectively), indicating insufficient satiety signals from the mouth and stomach alone.
    • Duodenal water infusions dose-dependently inhibited sham drinking, while saline had no effect, suggesting a specific role for water absorption or osmolality in the distal intestine.

    Conclusions:

    • Oropharyngeal stimulation and gastric passage of water are insufficient to terminate drinking in rhesus monkeys.
    • Post-absorptive signals originating in the intestine, distal to the duodenum, are critical for inhibiting excessive water intake.
    • These findings highlight the complex interplay of sensory and post-absorptive cues in regulating fluid homeostasis.

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