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[Changes in left ventricular regional wall motion induced by Verapamil (author's transl)]
Giornale Italiano Di Cardiologia
|January 1, 1980
Summary
Verapamil improved regional heart wall motion in 65% of patients with coronary artery disease. However, it showed no significant effect on areas with prior heart attacks, similar to other calcium channel blockers.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Coronary artery disease (CAD) affects heart wall motion.
- Verapamil is a calcium channel blocker with potential cardiovascular effects.
Purpose of the Study:
- To evaluate the effect of intravenous verapamil on regional heart wall motion in patients with CAD.
- To compare verapamil's efficacy with other vasodilators.
Main Methods:
- Cineventriculography was performed before and after verapamil administration in 28 subjects.
- Regional wall motion analysis was conducted using two distinct methodologies.
Main Results:
- Improved regional wall motion was observed in approximately 65% of the studied cases.
- No significant improvement was noted in myocardial segments affected by previous infarctions.
- The observed effects were comparable to those of nitroglycerin and other calcium antagonists.
Conclusions:
- Intravenous verapamil can enhance regional heart wall motion in a majority of patients with CAD.
- Verapamil's effectiveness is limited in areas with established myocardial infarction.
- Verapamil demonstrates similar functional responses to other calcium channel blockers in this context.