Serum levels of immunoglobulin G subclasses in Nigerians

IgG subclass levels were determined in 128 apparently normal Nigerian subjects aged 6--42 years, using a modified radial immunodiffusion technique. IgG1 constituted the major subclass with about 70% of the total IgG. IgG4 subclass was the least with about 0.5%. The concentrations of IgG2 and IgG3 were 27% and 1.5% of the total IgG respectively. There was no systematic effect of age on all the subclasses. IgG1 and IgG2 levels were higher in females than in males but there were no marked differences in the IgG3 and IgG4 levels between the sexes.