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[Antibiotic resistance of Pseudomonas aeruginosa strains isolated from patients with infected burns]
Abstract:
Sensitivity to 15 drugs of 248 P. aeruginosa strains isolated from patients with infected burns was studied by the method of agar dilution. All of the strains were resistant to polymyxin M, ceporin, erythromycin and oleandomycin. Most of the strains were resistant to streptomycin, monomycin, ampicillin and rifadin. Moderate resistance of the strains to carbenicillin, morphocycline, vibramycin, kanamycin, tetraolean and tetracycline was observed: the maximum concentrations of these antibiotics (128 microgram/ml) inhibited the growth of 85, 69, 63, 51.8, 43.6 and 41.2 per cent of the strains respectively. Gentamicin proved to be most active against the strains of P. aeruginosa and inhibited 87 per cent of the strains when used in the therapeutic doses. The study provided recomendation of the drugs for parenteral and local use in treatment of burns infected with P. aeruginosa.
Insights
Pseudomonas aeruginosa (P. aeruginosa) strains from burn infections show high resistance to many antibiotics. Gentamicin demonstrated the most activity, offering potential treatment options for infected burns.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Pseudomonas aeruginosa (P. aeruginosa) is a common opportunistic pathogen.
- Infected burns present a significant clinical challenge due to potential P. aeruginosa colonization and infection.
- Antibiotic resistance in P. aeruginosa complicates treatment strategies.
Purpose of the Study:
- To evaluate the in vitro sensitivity of P. aeruginosa strains isolated from infected burn patients to a panel of 15 antimicrobial drugs.
- To identify antibiotics with significant activity against these resistant strains for potential therapeutic use.
Main Methods:
- Agar dilution method was employed to test the susceptibility of 248 P. aeruginosa isolates.
- Isolates were obtained from patients with infected burns.
- Minimum inhibitory concentrations (MICs) were determined for 15 different drugs.
Main Results:
- All 248 strains exhibited resistance to polymyxin M, ceporin, erythromycin, and oleandomycin.
- High resistance rates were observed for streptomycin, monomycin, ampicillin, and rifampicin.
- Gentamicin was the most effective antibiotic, inhibiting 87% of P. aeruginosa strains at therapeutic doses.
- Moderate resistance was noted for carbenicillin, morphocycline, vibramycin, kanamycin, tetraolean, and tetracycline.
Conclusions:
- P. aeruginosa strains from infected burns display extensive multi-drug resistance.
- Gentamicin is recommended as a primary therapeutic option for parenteral and local treatment of P. aeruginosa-infected burns.
- Further surveillance of antibiotic resistance patterns is crucial for effective clinical management.