Pregnancies in primary amenorrhea with normally developed secondary sex characteristics

We report herein 11 pregnancies in patients with primary amenorrhea and normally developed secondary sex characteristics. All patients were fully investigated, and their ovaries as visualized by laparotomy or laparoscopy were found to be small. Ovarian biopsy revealed numerous unstimulated primordial follicles. The hormonal profiles showed hypoestrogenism with atrophic endometrium. Human gonadotropins were used in large amounts in order to achieve pregnancy. Two patients responded in all treatment cycles with menses. The remainder failed to respond to all treatment cycles. All patients became pregnant and carried their pregnancies normally to term. There were four sets of twins and seven single births. Of fifteen newborns, one died of congenital heart disease.