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[Metabolic interaction of valproic acid (author's transl)]
Die Pharmazie
|January 1, 1980
Abstract:
Valproic acid produces a marked competitive inhibition of the aminophenazone N-demethylation and the codeine phosphate O-demethylation by 9000 g-supernatant of rat liver homogenates, but it exerts virtually no effect on the aniline hydroxylation and the p-nitrophenol glucuronidation which are slightly inhibited only if its tenfold amount is allowed to react on the substrate.