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Primary cutaneous aspergillosis.

S A Estes, A A Hendricks, W G Merz

    Journal of the American Academy of Dermatology
    |October 1, 1980
    PubMed
    Summary
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    A child with leukemia developed Aspergillus flavus skin infections at IV sites. Treatment with amphotericin B and granulocyte transfusion led to resolution.

    Area of Science:

    • Medical Mycology
    • Hematology
    • Pediatric Oncology

    Background:

    • Acute monocytic leukemia (AML) is a serious hematologic malignancy.
    • Therapy-induced leukopenia significantly increases infection risk in pediatric cancer patients.
    • Intravenous (IV) access sites are potential portals for opportunistic infections.

    Observation:

    • A 6-year-old boy with AML and severe leukopenia presented with necrotizing skin lesions.
    • Lesions were localized to areas of IV catheter insertion on the arm and hand.
    • Clinical presentation suggested a localized infectious process.

    Findings:

    • Biopsy and cultures confirmed Aspergillus flavus as the causative agent of the skin lesions.
    • No evidence of systemic dissemination of the fungal infection was detected.

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  • The patient received systemic amphotericin B and granulocyte transfusion for treatment.

    • Implications:

    • This case highlights the risk of localized Aspergillus flavus infections at IV sites in immunocompromised children.
    • Prompt diagnosis and targeted antifungal therapy are crucial for managing such infections.
    • Granulocyte transfusions may be a valuable adjunct in treating severe invasive fungal infections in neutropenic patients.