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Related Experiment Videos

Necrotizing external otitis.

E Rubinstein, E Ostfeld, S Ben-Zaray

    Pediatrics
    |October 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Necrotizing external otitis, a severe ear infection, can occur in infants undergoing chemotherapy for neuroblastoma. Prompt, aggressive treatment including antibiotics and potential surgery is crucial for recovery.

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    Area of Science:

    • Pediatric Oncology
    • Infectious Diseases
    • Otolaryngology

    Background:

    • Cytostatic therapy for neuroblastoma can predispose infants to opportunistic infections.
    • Necrotizing external otitis (NEO) is a severe infection affecting the external ear canal, skin, and cartilage.
    • Infants with compromised immune systems are at higher risk for severe infections.

    Observation:

    • A case of necrotizing external otitis is described in an infant undergoing cytostatic therapy for neuroblastoma.
    • The infection was characterized by invasive necrosis of the external ear's skin and cartilage.
    • Pseudomonas aeruginosa was identified as the primary pathogen responsible for the infection.

    Findings:

    • NEO should be suspected in infants with serious underlying conditions presenting with external otitis unresponsive to standard local treatments.

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  • The typical pathogen isolated is Pseudomonas aeruginosa.
  • Aggressive antibiotic therapy is the cornerstone of treatment.

    • Implications:

    • Early recognition and prompt, vigorous treatment are essential for managing NEO in immunocompromised infants.
    • Surgical intervention may be necessary in severe cases.
    • This condition highlights the importance of vigilant monitoring for infections in pediatric cancer patients receiving chemotherapy.