Jove
Visualize
Contact Us

Related Experiment Videos

Endotoxin in meningococcal infections.

H R Tubbs

    Archives of Disease in Childhood
    |October 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    In children with meningococcal infections, endotoxin levels did not correlate with disease severity. However, high cerebrospinal fluid antigen levels in meningitis patients indicated a poor prognosis, impacting clinical outcomes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Exchange transfusion in severe falciparum malaria.

    Transactions of the Royal Society of Tropical Medicine and Hygiene·1985
    Same author

    Pneumococcal serotypes in West Africa.

    Lancet (London, England)·1980
    Same author

    Obstructive jaundice and portal vein calcification.

    The British journal of radiology·1978
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Pediatric Infectious Diseases
    • Clinical Microbiology
    • Immunology

    Background:

    • Meningococcal infections pose a significant threat to children, with outcomes influenced by complex host-pathogen interactions.
    • Understanding the role of bacterial components like endotoxin and host immune responses, including complement activation and coagulation, is crucial for predicting disease severity.

    Purpose of the Study:

    • To investigate the relationship between plasma and cerebrospinal fluid endotoxin levels and clinical outcomes in pediatric meningococcal infections.
    • To assess the correlation between endotoxin levels, antigen levels, complement activation, disseminated intravascular coagulation, and prognosis in affected children.

    Main Methods:

    • Analysis of plasma and cerebrospinal fluid samples from 26 children diagnosed with meningococcal infections.

    Related Experiment Videos

  • Measurement of endotoxin, antigen levels, complement activation markers, and disseminated intravascular coagulation indices.
  • Correlation of laboratory findings with clinical outcomes and patient prognosis.

    • Main Results:

    • No significant association was found between plasma or cerebrospinal fluid endotoxin levels and clinical outcomes, complement activation, or disseminated intravascular coagulation.
    • Elevated levels of meningococcal antigen in the cerebrospinal fluid were strongly associated with a poor clinical prognosis in patients with meningitis.

    Conclusions:

    • Endotoxin levels do not appear to be a reliable indicator of disease severity or associated complications in pediatric meningococcal infections.
    • Cerebrospinal fluid antigen levels serve as a valuable prognostic marker for children with meningococcal meningitis, highlighting the importance of early detection and management.