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Avoidance behavior in rats selectively bred for differential alcohol sensitivity.

N R Shapiro, E P Riley

    Psychopharmacology
    |January 1, 1980
    PubMed
    Summary
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    Most affected (MA) and least affected (LA) rats exhibit distinct avoidance learning behaviors. Alcohol challenges reveal greater performance deficits in MA rats, highlighting alcohol

    Area of Science:

    • Neuroscience
    • Behavioral Genetics
    • Pharmacology

    Background:

    • Selective breeding has generated rat lines with extreme motor impairments after alcohol exposure.
    • Understanding behavioral differences between these lines is crucial for studying alcohol's effects.

    Purpose of the Study:

    • To investigate performance differences in active avoidance tasks between alcohol-sensitive (MA) and alcohol-resilient (LA) rat lines.
    • To determine if alcohol administration exacerbates existing behavioral differences.

    Main Methods:

    • Utilized two active avoidance tasks: one-way and two-way shuttle avoidance.
    • Compared performance (acquisition, latency, percent avoidances) between MA and LA rats over multiple days.
    • Administered alcohol to assess its impact on avoidance behavior in both lines.

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    Main Results:

    • MA rats outperformed LA rats in two-way avoidance, showing better response latencies and avoidances.
    • MA rats demonstrated superior initial acquisition in one-way avoidance, though this difference diminished with training.
    • Alcohol administration induced greater performance deficits in MA rats compared to LA rats across both tasks.

    Conclusions:

    • Line differences in avoidance learning are evident and generalize to aversively motivated tasks.
    • Alcohol sensitivity is associated with greater performance impairment in avoidance learning.
    • Avoidance learning differences represent a significant non-drug-related phenotype in these selectively bred rat lines.