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Calcium antagonists in exercise-induced asthma.

British Medical Journal (Clinical Research Ed.)

|March 21, 1981

Summary

Inhaled verapamil and sodium cromoglycate effectively protected against exercise-induced asthma by preventing bronchoconstriction. Both treatments showed comparable efficacy, suggesting calcium

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Area of Science:

Pulmonary Medicine
Pharmacology

Background:

Exercise-induced asthma (EIA) is a common condition characterized by bronchoconstriction following physical exertion.
The role of mediator release, particularly calcium-dependent pathways, in EIA pathophysiology is increasingly recognized.

Purpose of the Study:

To compare the protective effects of inhaled verapamil and sodium cromoglycate against exercise-induced bronchoconstriction in patients with asthma.
To investigate the potential role of calcium channels in EIA by assessing the efficacy of a calcium antagonist.

Main Methods:

A single-blind trial involving ten patients with EIA.
Comparison of inhaled verapamil (3 mg), sodium cromoglycate (12 mg), and saline (control).
Assessment of maximal percentage fall in forced expiratory volume in one second (FEV1) after standardized treadmill exercise.

Main Results:

Saline inhalation resulted in a significant fall in FEV1 (45.4%).
Both sodium cromoglycate (18.4% fall) and verapamil (16.7% fall) significantly attenuated exercise-induced bronchoconstriction compared to saline.
The protective effects of verapamil and sodium cromoglycate were comparable and statistically significant (p<0.01 and p<0.02, respectively).

Conclusions:

Inhaled verapamil and sodium cromoglycate demonstrate comparable efficacy in preventing exercise-induced bronchoconstriction.
The findings support the hypothesis that calcium-dependent mediator release plays a crucial role in EIA.
Calcium antagonists, like verapamil, may offer a therapeutic strategy for managing EIA by blocking calcium channels.

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