Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Testicular function in varicocele.

T Pasqualini, H Chemes, R Coco

    International Journal of Andrology
    |December 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Stress and the reproductive axis.

    Journal of neuroendocrinology·2014
    Same author

    [A case of acute renal failure secondary to late-onset McArdle's disease].

    Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2013
    Same author

    4-mer hyaluronan oligosaccharides stimulate inflammation response in synovial fibroblasts in part via TAK-1 and in part via p38-MAPK.

    Current medicinal chemistry·2013
    Same author

    Male hypogonadism: an extended classification based on a developmental, endocrine physiology-based approach.

    Andrology·2012
    Same author

    The role of asynapsis in human spermatocyte failure.

    International journal of andrology·2011
    Same author

    A new therapy for kidney injury: regeneration.

    European review for medical and pharmacological sciences·2011
    Same journal

    News from the European Academy of Andrology (EAA).

    International journal of andrology·2018
    Same journal

    The EAA International Quality Control Programme for Y-Chromosomal Microdeletions.

    International journal of andrology·2018
    Same journal

    Cell surface molecules of human teratoma cell lines.

    International journal of andrology·2017
    Same journal

    Foreword.

    International journal of andrology·2017
    Same journal

    Discussion.

    International journal of andrology·2017
    Same journal

    Discussion.

    International journal of andrology·2017
    See all related articles

    Varicocele can affect sperm production, but high testicular testosterone levels, despite altered Leydig cell function, suggest spermatogenesis failure isn't due to low testosterone. Luteinizing hormone (LH) stimulation may compensate.

    Area of Science:

    • Reproductive Endocrinology
    • Andrology
    • Urology

    Background:

    • Varicocele is a common cause of male infertility.
    • Leydig cell function and testosterone production are crucial for spermatogenesis.

    Purpose of the Study:

    • To investigate testicular testosterone levels and their relationship with spermatogenesis in patients with varicocele.
    • To determine if impaired Leydig cell function contributes to infertility in varicocele.

    Main Methods:

    • Evaluated serum testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), sperm count, and testicular histology in 17 varicocele patients.
    • Measured intratesticular testosterone concentration.

    Main Results:

    • Testicular testosterone was normal to high (mean 906 +/- 723 ng/g).

    Related Experiment Videos

  • Serum testosterone was mostly normal; LH was elevated in 50% of patients.
  • Testicular damage varied and correlated with sperm analysis, with higher testicular testosterone in severe lesions.

    • Conclusions:

    • Leydig cell function is partially altered in varicocele but compensated by LH stimulation.
    • Spermatogenesis failure in varicocele is not primarily caused by low testosterone levels.