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Bone changes in end-stage oxalosis.

D Brancaccio, A Poggi, C Ciccarelli

AJR. American Journal of Roentgenology

|May 1, 1981

Summary

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Primary hyperoxaluria causes excess oxalic acid, leading to kidney stones and failure. Dialysis can cause calcium oxalate crystal buildup in bones and tissues, a condition detailed in this report.

Area of Science:

Nephrology
Metabolic Diseases
Radiology

Background:

Primary hyperoxaluria is a rare genetic disorder of exaggerated oxalic acid production.
It leads to recurrent kidney stones, progressive kidney failure, and early mortality.

Observation:

Patients undergoing chronic dialysis may develop a secondary syndrome.
This involves intense calcium oxalate crystal deposition in soft tissues and bones.

Findings:

This study reports radiologic findings in four adult patients with chronic renal dialysis.
These patients exhibited histologic and clinical evidence of massive bone oxalosis.

Implications:

Understanding oxalate deposition is crucial for managing advanced primary hyperoxaluria.

Related Experiment Videos

Radiologic assessment aids in diagnosing and monitoring bone oxalosis in dialysis patients.