Related Experiment Video
Updated: Aug 11, 2026
10:03
Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
Published on: November 5, 2019
Urethritis caused by Neisseria meningitidis
Journal of Clinical Microbiology
|August 1, 1980
Summary
A glucose-negative Neisseria meningitidis strain (group B) was identified from a meningitis patient. This case highlights Neisseria identification methods for bacterial meningitis diagnosis.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Diagnostics
Background:
- Neisseria meningitidis is a leading cause of bacterial meningitis globally.
- Accurate identification of Neisseria species is crucial for appropriate treatment and public health response.
- Meningitis remains a significant public health concern, particularly in certain age groups.
Observation:
- A specific strain of Neisseria meningitidis, characterized as glucose-negative and belonging to group B, was isolated from a patient diagnosed with meningitis.
- The isolate presented unique biochemical characteristics differentiating it from typical Neisseria meningitidis strains.
- Standard microbiological techniques were employed for the initial isolation and characterization of the pathogen.
Findings:
- The study details the successful isolation and preliminary characterization of a glucose-negative, group B Neisseria meningitidis strain.
- Biochemical profiling confirmed the isolate's identity as Neisseria meningitidis, despite its unusual glucose fermentation pattern.
- A review of established Neisseria identification procedures was conducted, emphasizing key diagnostic steps.
Implications:
- This finding expands the known biochemical diversity within Neisseria meningitidis.
- It underscores the importance of comprehensive identification protocols to avoid misclassification of Neisseria species.
- Enhanced diagnostic strategies may improve the management of meningitis cases caused by atypical strains.
Related Concept Videos
01:27Acute Pyelonephritis I: Introduction
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
01:24Bacterial Meningitis
Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
01:18Viral Meningitis
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
01:22Bacterial Meningitis I: Introduction
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
01:26Bacterial Meningitis II: Pathophysiology
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
01:19Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...