Experimental Chagas' disease in dogs. A pathologic and ECG study of the chronic indeterminate phase of the infection

Pathology of the chronic latent phase of Chagas' disease is poorly understood. In our experiment, nine dogs were inoculated with Trypanosoma cruzi and acute disease developed within 15 to 25 days, followed by a chronic asymptomatic period that varied from eight months to three years, at which time the animals were killed. Although ECG changes were minimal, all animals showed a mild focal chronic myocarditis, with a few microscopic foci of fibrosis. Focal or diffuse fibrosis, scleroatrophy, and fatty replacement were present in various parts of the conducting system, especially in the atrioventricular node, the distal portion of His' main bundle, and the initial portion of the right bundle. These lesions were considered to be sequelae from inflammation and necrosis during the acute phase of the infection. In addition to characterizing the lesions of the chronic indeterminate phase of Chagas' disease in the canine model, the present findings suggest that the lesions may be responsible for ECG changes that may appear in subjects with otherwise asymptomatic T cruzi infection.