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Epileptic cases of late onset with the diffuse slow spike-wave
Folia Psychiatrica Et Neurologica Japonica
|January 1, 1981
Summary
Late-onset epilepsy, characterized by diffuse slow spike-wave on EEG, presents differently in patients. Some develop Lennox-Gastaut syndrome, exhibiting worse seizure and cognitive outcomes.
Area of Science:
- Neurology
- Epileptology
- Clinical Neuroscience
Background:
- Investigating epilepsy with diffuse slow spike-wave patterns and late symptom onset (age 7+).
- Examining 22 cases to differentiate clinical presentations and prognoses.
Observation:
- Half of the cases exhibited symptoms consistent with Lennox-Gastaut syndrome.
- The remaining half presented with absence, psychomotor, or grand mal seizures.
Findings:
- Patients with Lennox-Gastaut syndrome showed poorer seizure control and intellectual outcomes.
- Atypical absence and atonic seizures were common, often preceded by other seizure types.
- These symptoms and diffuse slow spike-wave EEG patterns typically emerged during adolescence.
Implications:
- Suggests a distinct subtype of epilepsy: "Lennox-Gastaut syndrome of late onset."
- Highlights the importance of EEG patterns and symptom progression in epilepsy diagnosis.
- Informs prognosis and management strategies for late-onset epilepsy with specific EEG findings.