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Chronic intestinal pseudo-obstruction.

E H Hirsh, D Brandenburg, T Hersh

    Journal of Clinical Gastroenterology
    |September 1, 1981
    PubMed
    Summary
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    Intestinal pseudo-obstruction (IP) is a rare gut motility disorder. Magnesium deficiency correction improved symptoms, while antibiotics helped malabsorption but not obstruction episodes.

    Area of Science:

    • Gastroenterology
    • Internal Medicine

    Background:

    • Intestinal pseudo-obstruction (IP) is a rare motility disorder mimicking mechanical obstruction.
    • Differentiating IP from mechanical obstruction is crucial for appropriate patient management.

    Observation:

    • This study reviewed 11 patients with IP over 5 years.
    • Common symptoms include abdominal distention, pain, nausea, and vomiting, with radiographic findings of dilated bowel loops.
    • Diarrhea, rather than obstipation, was a key differentiator from mechanical obstruction.

    Findings:

    • IP was associated with conditions like scleroderma, amyloidosis, celiac disease, and spinal cord injury.
    • Antibiotics resolved steatorrhea due to bacterial overgrowth but did not prevent pseudo-obstruction episodes.
    • Magnesium deficiency was noted in 7 patients, and its correction ameliorated symptoms.

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  • Metoclopramide showed variable efficacy in reducing pseudo-obstruction episodes.

    • Implications:

    • Identifying and correcting magnesium deficiency may be a key therapeutic strategy for IP.
    • Understanding associated conditions aids in diagnosing and managing IP.
    • Further research is needed to elucidate the pathophysiology and optimize treatment for IP.