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Plasminogen in the chick embryo. Transport and biosynthesis
The Journal of Biological Chemistry
|December 10, 1981
Summary
Chick embryo development relies on plasminogen, a key protein. This study shows plasminogen is stored in egg yolk and synthesized by the embryo, ensuring its availability for crucial developmental processes.
Area of Science:
- Developmental Biology
- Molecular Biology
- Embryology
Background:
- Plasminogen activation plays a role in biological processes.
- Understanding plasminogen's role in embryonic development is crucial.
Purpose of the Study:
- To investigate the metabolism and potential roles of plasminogen during chick embryonic development.
Main Methods:
- Studied plasminogen in chick embryos.
- Analyzed plasminogen presence in egg yolk and embryonic circulation.
- Investigated de novo synthesis of plasminogen.
Main Results:
- Plasminogen is abundant in the yolk of unincubated eggs.
- Intact plasminogen is transferred from yolk to embryonic circulation.
- Embryonic de novo synthesis of plasminogen occurs early in development.
Conclusions:
- The yolk serves as a significant reservoir for embryonic plasminogen.
- Combined yolk supply and embryonic synthesis ensure plasminogen availability throughout development.
- Plasminogen is essential for morphogenetic events during embryonic life.