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[Noxytioline in the local treatment of empyema (author's transl)]
Abstract:
The importance assumed by local treatment in non-tuberculous purulent pleurisy has suggested that intrapleural applications of a broad spectrum antiseptic could be as useful as in peritonitis. Fifteen adult patients with empyema secondary, in most cases, to local, usually Gram-negative, infections were treated with combined antibiotic therapy and locally administered noxytioline. The patients underwent 3 to 30 intrapleural lavages (average 9) via a pleurotomy drainage tube (11 cases) or after pleural puncture (4 cases). Results were very satisfactory in 12 out of 15 cases, with mild pleural sequelae in 8 cases. No local or systemic reactions were observed. This treatment proved particularly effective in 5 difficult cases.
Insights
Local antiseptic treatment with noxytioline alongside antibiotics effectively treated non-tuberculous purulent pleurisy in 15 adult patients. This approach showed high satisfaction rates and was particularly beneficial for complex empyema cases.
Area of Science:
- Thoracic Medicine
- Infectious Diseases
- Antimicrobial Therapy
Context:
- Non-tuberculous purulent pleurisy, often secondary to Gram-negative infections, presents a significant clinical challenge.
- Local intrapleural treatment is crucial for managing empyema effectively.
- The efficacy of broad-spectrum antiseptics in pleural infections warrants investigation.
Purpose:
- To evaluate the effectiveness and safety of intrapleural noxytioline combined with antibiotic therapy for treating adult patients with empyema.
- To assess the outcomes of this combined treatment in cases of purulent pleurisy.
- To determine the feasibility of intrapleural antiseptic application in managing pleural infections.
Summary:
- Fifteen adult patients with empyema received combined antibiotic therapy and intrapleural noxytioline through lavages via drainage tubes or pleural puncture.
- Treatment involved 3 to 30 intrapleural lavages (average 9) per patient.
- Highly satisfactory results were achieved in 12 out of 15 patients, with mild pleural sequelae in 8 cases and no observed adverse reactions.
Impact:
- This combined therapeutic approach demonstrated significant success in treating purulent pleurisy, including challenging cases.
- Intrapleural noxytioline offers a promising adjunctive treatment option for empyema management.
- The study supports the utility of local antiseptic application in improving outcomes for pleural infections.