Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Testicular function after renal transplantation.

D J Handelsman, V L Ralec, D J Tiller

    Clinical Endocrinology
    |May 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Reproducibility of Serum Androgen Concentrations by Liquid Chromatography Mass Spectrometry in Healthy Male and Female Athletes.

    Drug testing and analysis·2026
    Same author

    Response to Letter to Editor From Brown et al.

    Drug testing and analysis·2025
    Same author

    Natural history of autologous sperm cryostorage.

    Human reproduction (Oxford, England)·2024
    Same author

    Haem Iron Intake Is Associated with Increased Major Adverse Cardiovascular Events, All-Cause Mortality, Congestive Cardiac Failure, and Coronary Revascularisation in Older Men: The Concord Health and Ageing in Men Project.

    The journal of nutrition, health & aging·2023
    Same author

    Estrone, sex hormone binding globulin and lipid profiles in older women: an observational study.

    Climacteric : the journal of the International Menopause Society·2023
    Same author

    The metabolic health of young men conceived using intracytoplasmic sperm injection.

    Human reproduction (Oxford, England)·2022
    Same journal

    Supraphysiological Glucocorticoid Doses and Pitfalls of Annual Biomarker Monitoring in Adults With CAH.

    Clinical endocrinology·2026
    Same journal

    Subacute Thyroiditis in Denmark: A Nationwide Study of 1763 Cases.

    Clinical endocrinology·2026
    Same journal

    Pubertal Dynamics of Sertoli and Leydig Cell Dysfunction in Klinefelter Syndrome.

    Clinical endocrinology·2026
    Same journal

    Regarding Non-Classical Presentations of Rare Hereditary Hypoparathyroidism: A Case Series of CASR, GNA11, and GATA3 Mutations in Parathyroidology.

    Clinical endocrinology·2026
    Same journal

    Dual Metabolic Burden of Polyendocrine Metabolic Ovarian Syndrome (PMOS) and Gestational Diabetes in Pregnancy: Impact on Neonatal Anthropometry: Insights From the Born in Bradford Cohort.

    Clinical endocrinology·2026
    Same journal

    Preoperative CALLY Index for Identifying Atypical Parathyroid Tumors.

    Clinical endocrinology·2026
    See all related articles

    Renal transplantation improved hypogonadism in most male recipients, but residual deficits in the hypothalamic-pituitary-testicular axis persisted, impacting gonadal function and fertility.

    Area of Science:

    • Endocrinology
    • Urology
    • Nephrology

    Background:

    • Male hypogonadism is a common complication in patients with end-stage renal disease.
    • Renal transplantation is a potential treatment option for reversing hypogonadism in these patients.

    Purpose of the Study:

    • To assess the long-term effects of renal transplantation on gonadal function in adult male recipients.
    • To identify factors influencing the recovery or persistence of hypogonadism post-transplantation.

    Main Methods:

    • Clinical assessment and hormonal assays (FSH, LH, prolactin, testosterone, oestradiol) were performed.
    • Luteinizing hormone-releasing hormone (LHRH) stimulation tests and semen analyses were conducted.
    • Correlation analysis was used to relate gonadal function to duration of pre-transplant hemodialysis.

    Related Experiment Videos

    Main Results:

    • Hypogonadism improved in 9 out of 16 patients post-transplantation.
    • Residual hypogonadism was observed in 7 out of 16 patients, correlating with longer pre-transplant hemodialysis duration (>1 year).
    • Subtle hypothalamic-pituitary-testicular axis defects, including elevated FSH and low testosterone, persisted even in clinically normal patients.

    Conclusions:

    • Renal transplantation can reverse hypogonadism in many male recipients, but long-term gonadal dysfunction may persist.
    • Duration of pre-transplant hemodialysis is a significant factor in residual hypogonadism.
    • Impaired hypothalamic-pituitary-testicular axis function remains a concern post-transplantation, affecting fertility and testicular parameters.