Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developing aspects of radiation oncology.

J F Fowler

    Medical Physics
    |July 1, 1981
    PubMed
    Summary

    Advanced radiotherapy techniques like proton and heavy ion beams offer improved dose distribution and biological advantages. These methods enhance tumor targeting while sparing healthy tissues, representing significant progress in cancer treatment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Hand eczema in children referred for patch testing: North American Contact Dermatitis Group Data, 2000-2016.

    The British journal of dermatology·2021
    Same author

    Phase III randomized study of the proposed adalimumab biosimilar GP2017 in psoriasis: impact of multiple switches.

    The British journal of dermatology·2018
    Same author

    Apremilast for the treatment of moderate-to-severe palmoplantar psoriasis: results from a double-blind, placebo-controlled, randomized study.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2017
    Same author

    Hyperfractionated radiotherapy.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2014
    Same author

    The effect of multiple small doses of X rays on skin reactions in the mouse and a basic interpretation. 1976.

    Radiation research·2012
    Same author

    21 years of biologically effective dose.

    The British journal of radiology·2010

    Area of Science:

    • Medical physics and radiobiology
    • Radiation oncology

    Background:

    • Modern radiotherapy seeks improved physical dose distributions for better tumor targeting.
    • High-energy particle beams like protons and heavy ions deposit a high dose at a specific depth.
    • Biological properties of radiation, such as linear energy transfer (LET), are crucial for therapeutic efficacy.

    Purpose of the Study:

    • To explore advancements in radiotherapy physics and radiobiology.
    • To evaluate the potential of novel radiation sources and therapeutic strategies.
    • To improve the treatment of radioresistant tumors and protect normal tissues.

    Main Methods:

    • Utilizing particle beams such as protons, heavy ions, and negative pi mesons for precise dose deposition.
    • Investigating the biological effects of high Linear Energy Transfer (LET) radiation from heavy ions and pions.
    • Exploring the use of radiosensitizing drugs for hypoxic cells and hyperthermia.
    • Testing radioprotecting drugs with differential uptake in tumors versus normal tissues.

    Main Results:

    • Particle beams offer superior physical dose distributions with a high-dose peak at depth.
    • High LET radiation from heavy ions and pions can overcome tumor radioresistance, particularly in hypoxic conditions.
    • Fast neutrons exhibit high LET properties comparable to certain heavy ions.
    • Hypoxic cell radiosensitizers, hyperthermia, and targeted radioprotectors show promise in enhancing treatment outcomes.

    Conclusions:

    • Advancements in radiotherapy physics and radiobiology are crucial for optimizing cancer treatment.
    • Particle therapy and biological modifiers offer promising avenues to improve tumor control and reduce normal tissue toxicity.
    • Further research into these areas is essential for developing more effective and precise radiotherapy strategies.

    Related Experiment Videos