Biogenesis of the C20 polyketide, aflatoxin. A review

Aflatoxin B2 is a secondary metabolite produced by the ubiquitous molds Aspergillus flavus and Aspergillus parasiticus. The toxin was first characterized in 1963 as the etiological agent responsible for the infamous "Turkey X' disease. Since that time, much information on its chemistry, toxicity and biological activity has accumulated. A significant amount of work has been done to elucidate its biosynthesis. Evidence indicates the polyketide route as its point of origin. The steps involved in the polyketide pathway, the six identified intermediated compounds, and the experimental techniques and analytical instrumentation used to procure information on aflatoxin biogenesis are included in this review.