[Effect of hydrocortisone on the acid hydrolase activity of the myocardium]

A study was made of the effect of hydrocortisone in doses of 10, 25 and 50 mg/kg on the activity of beta-glucosidase, beta-galactosidase and acid phosphatase in the rat heart 1, 3, 6, 12 and 24 hours after single administration of the drug. It was found that the hormone exhibited a stabilizing effect within the first hours of the experiments. Later on labilization of the lysosomal membranes of the myocardium could be observed. The increasing hydrocortisone concentrations induced dose-dependent changes in the activity of the test enzymes.