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Related Experiment Videos

Changes on computed cranial tomography with aging: intracranial fluid volume.

L M Zatz, T L Jernigan, A J Ahumada

    AJNR. American Journal of Neuroradiology
    |January 1, 1982
    PubMed
    Summary

    Brain fluid volumes, including ventricular and sulcal fluid, remain stable until age 60, then increase. This study analyzed computed tomography scans to quantify these changes in normal adults.

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    Area of Science:

    • Neuroimaging
    • Gerontology
    • Quantitative Anatomy

    Background:

    • Accurate quantification of intracranial fluid volumes is crucial for understanding brain aging and disease.
    • Previous methods for estimating fluid volumes from computed tomography (CT) scans have limitations.

    Purpose of the Study:

    • To develop and validate a semiautomated computer analysis for estimating ventricular and sulcal fluid volumes from CT scans.
    • To establish normative values for these fluid volumes across a wide age range in healthy adults.
    • To investigate age-related trends and sex differences in intracranial fluid volumes.

    Main Methods:

    • Semiautomated computer analysis of CT scans to estimate fluid volumes.
    • Analysis of 123 normal subjects aged 23-88 years.

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  • Statistical analysis to assess age trends, sex differences, and relationships with skull size.

    • Main Results:

    • A wide range of normal values for ventricular and sulcal fluid was observed.
    • Fluid volumes remained relatively constant until age 60, then increased progressively.
    • Ventricular and sulcal enlargement could occur independently.
    • Ventricle size correlated with skull size; no sex difference in ventricle size was found after accounting for skull size.
    • Cranial cavity and left hemicranium/ventricle were larger on average than their right counterparts in both sexes.

    Conclusions:

    • The developed method provides a reliable estimation of intracranial fluid volumes.
    • Age-related increases in ventricular and sulcal fluid become significant after 60 years.
    • Skull size is a key factor in determining ventricle size, masking potential sex differences.