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Related Experiment Videos

Valproate tremors.

B J Karas, B J Wilder, E J Hammond

    Neurology
    |April 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Valproic acid can induce a tremor similar to essential tremor within a month of starting therapy. This tremor is common at higher doses, affecting most patients studied.

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    Area of Science:

    • Neurology
    • Pharmacology

    Background:

    • Valproic acid is a widely used antiepileptic and mood-stabilizing drug.
    • Drug-induced tremors are a known but often underreported side effect of various medications.

    Purpose of the Study:

    • To characterize the accelerometric features of tremor induced by valproic acid.
    • To investigate the onset, characteristics, and dose-dependency of valproic acid-induced tremor.

    Main Methods:

    • Accelerometric recordings were used to quantify tremor.
    • Patient data on valproic acid dosage and plasma levels were collected.
    • Clinical assessment of tremor characteristics (rest, action, positioning) was performed.

    Main Results:

    • Tremor, similar to essential tremor, appeared within one month of valproic acid therapy.

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  • Tremor was present at rest and worsened with action or antigravity positioning.
  • Dosages over 750 mg/day were typically associated with tremor, affecting 20 of 25 patients.

    • Conclusions:

    • Valproic acid commonly induces a clinically significant tremor.
    • Tremor severity did not strongly correlate with plasma valproate levels.
    • Awareness of this potential side effect is crucial for clinicians managing patients on valproic acid.