Selenium 75-selenofolate metabolism and radiation dosimetry.

Area of Science:

• Pharmacokinetics and Radiation Dosimetry
• Nutritional Biochemistry

Background:

• Understanding the absorption and distribution of folate analogs is crucial for drug development and nutritional studies.
• 75Se-selenofolate is a radiolabeled compound used to trace folate metabolism and distribution in vivo.

Purpose of the Study:

• To determine the absorption and whole-body distribution of orally administered 75Se-selenofolate in healthy volunteers.
• To calculate the radiation dose to the liver and the effective dose equivalent based on metabolic data.

Main Methods:

• Oral administration of 75Se-selenofolate to two healthy volunteers.
• Whole-body counting to measure retention of the radiolabeled compound.
• Hybrid scanning to determine the distribution of 75Se-selenofolate throughout the body.
• Calculation of radiation dose and effective dose equivalent using obtained metabolic data.

Main Results:

• Approximately 65% of the orally administered 75Se-selenofolate dose was absorbed from the gastrointestinal tract.
• Whole-body retention and distribution patterns were quantified.
• Integrated radiation dose to the liver and effective dose equivalent were calculated.

Conclusions:

• Oral administration of 75Se-selenofolate results in significant gastrointestinal absorption.
• The study provides essential pharmacokinetic and dosimetry data for 75Se-selenofolate, informing future research and potential clinical applications.